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Target
NAD-dependent protein deacylase sirtuin-6
Ligand
BDBM50257405
Substrate
n/a
Meas. Tech.
ChEMBL_879914 (CHEMBL2211908)
IC50
47000±n/a nM
Citation
 Kokkonen, P; Rahnasto-Rilla, M; Kiviranta, PH; Huhtiniemi, T; Laitinen, T; Poso, A; Jarho, E; Lahtela-Kakkonen, M Peptides and Pseudopeptides as SIRT6 Deacetylation Inhibitors. ACS Med Chem Lett 3:969-974 (2012) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacylase sirtuin-6
Synonyms:
NAD-dependent protein deacetylase sirtuin-6 | NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | Regulatory protein SIR2 homolog 6 | SIR2-like protein 6 | SIR2L6 | SIR6_HUMAN | SIRT6 | Sirtuin-6 (SIRT6)
Type:
Protein
Mol. Mass.:
39133.03
Organism:
Human
Description:
Q8N6T7
Residue:
355
Sequence:
MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
  
Inhibitor
Name:
BDBM50257405
Synonyms:
Ala-Lys-Lys(epsilon-thioAc)Leu-Met | CHEMBL504711
Type:
Small organic molecule
Emp. Form.:
C28H53N7O6S2
Mol. Mass.:
647.894
SMILES:
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)N)C(O)=O |r|
Structure:
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