Reaction Details Report a problem with these data
Target
Isoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)
Ligand
BDBM50427841
Substrate
n/a
Meas. Tech.
ChEMBL_940755 (CHEMBL2330135)
IC50
121±n/a nM
Citation
 Jiang, XR; Wang, P; Smith, CL; Zhu, BT Synthesis of novel estrogen receptor antagonists using metal-catalyzed coupling reactions and characterization of their biological activity. J Med Chem 56:2779-90 (2013) [PubMed]  Article 
Target
Name:
Isoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)
Synonyms:
ERR beta-2 | ERR-beta | ERR2_HUMAN | ERRB2 | ESRL2 | ESRRB | Estrogen receptor-like 2 | Estrogen-related receptor beta | Estrogen-related receptor, beta | NR3B2 | Nuclear receptor subfamily 3 group B member 2 | Steroid hormone receptor ERR2 | Steroid hormone receptor ERR2 (ERRbeta2-delta10)
Type:
PROTEIN
Mol. Mass.:
56220.72
Organism:
Homo sapiens (Human)
Description:
ChEMBL_940755
Residue:
508
Sequence:
MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPPMFAGAGLGGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKVGQEQLRGSPKDERMSSHDGKCPFQSAAFTSRDQSNSPGIPNPRPSSPTPLNERGRQISPSTRTPGGQGKHLWLTM
  
Inhibitor
Name:
BDBM50427841
Synonyms:
CHEMBL2326073
Type:
Small organic molecule
Emp. Form.:
C34H38O2
Mol. Mass.:
478.6643
SMILES:
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)[C@H](CCCCC#Cc1ccc2ccccc2c1)Cc1cc(O)ccc31 |r|
Structure:
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