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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50010306
Substrate
n/a
Meas. Tech.
ChEMBL_1340419 (CHEMBL3253107)
IC50
3000±n/a nM
Citation
 Carnmalm, B; Rämsby, S; Renyi, AL; Ross, SB; Ogren, SO Antidepressant agents. 9. 3,3-Diphenylcyclobutylamines, a new class of central stimulants. J Med Chem 21:78-82 (1978) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | Htt | SC6A4_MOUSE | Serotonin transporter | Sert | Slc6a4 | Sodium-dependent serotonin transporter | Solute carrier family 6 member 4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70044.92
Organism:
MOUSE
Description:
5-HT Transporter SLC6A4 MOUSE::Q60857
Residue:
630
Sequence:
METTPLNSQKVLSECKDKEDCQENGVLQKGVPTPADKAGPGQISNGYSAVPSTSAGDEAPHSTPAATTTLVAEIHQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWKKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLALCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCILGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVVVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIILGYCIGTSSVICIPIYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
  
Inhibitor
Name:
BDBM50010306
Synonyms:
CHEMBL3251302
Type:
Small organic molecule
Emp. Form.:
C17H20ClN
Mol. Mass.:
273.8
SMILES:
Cl.CNC1CC(C1)(c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: