Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Sodium- and chloride-dependent betaine transporter
Ligand
BDBM50021385
Substrate
n/a
Meas. Tech.
ChEMBL_1362705 (CHEMBL3294686)
IC50
5888±n/a nM
Citation
Kowalczyk, P; Salat, K; Höfner, GC; Mucha, M; Rapacz, A; Podkowa, A; Filipek, B; Wanner, KT; Kulig, K Synthesis, biological evaluation and structure-activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides. Eur J Med Chem 83:256-73 (2014) [PubMed] Article More Info.:
Target
Name:
Sodium- and chloride-dependent betaine transporter
Synonyms:
GABA transporter | GABA transporter 2 | Gabt2 | Gat-2 | Gat2 | S6A12_MOUSE | Slc6a12
Type:
PROTEIN
Mol. Mass.:
69615.88
Organism:
Mus musculus
Description:
ChEMBL_1460088
Residue:
614
Sequence:
MDRKVAVHEDGYPVVSWVPEEGEMMDQKGKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNHSSARGVSSSENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMSQEQGIPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLLFLGLDSQFVCMECLVTASMDMFPQQLRKSGRRDVLILAISVLCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNVYMYPSWGYSIGWLLAFSSMACVPLFIIITFLKTQGSFKKRLRRLITPDPSLPQPGRRPPQDGSSAQNCSSSPAKQELIAWEKETHL
Inhibitor
Name:
BDBM50021385
Synonyms:
CHEMBL3289583
Type:
Small organic molecule
Emp. Form.:
C30H35N3O
Mol. Mass.:
453.6184
SMILES:
[#6]-c1ccc(-[#6]-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#7])-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6](/c2ccccc2)-c2ccccc2)cc1
Structure:
