Reaction Details Report a problem with these data
Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Ligand
BDBM50168829
Substrate
n/a
Meas. Tech.
ChEMBL_1577533 (CHEMBL3806942)
IC50
2370±n/a nM
Citation
 Ai, T; Wilson, DJ; More, SS; Xie, J; Chen, L 5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors. J Med Chem 59:2928-41 (2016) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms:
NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3
Type:
Protein
Mol. Mass.:
43582.69
Organism:
Homo sapiens (Human)
Description:
Q9NTG7
Residue:
399
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
  
Inhibitor
Name:
BDBM50168829
Synonyms:
CHEMBL3805130
Type:
Small organic molecule
Emp. Form.:
C22H17N3O4
Mol. Mass.:
387.3881
SMILES:
NC(=O)c1cncc(OCc2cccc(NC(=O)c3cc4ccccc4o3)c2)c1
Structure:
Search PDB for entries with ligand similarity: