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Target
Potassium two pore domain channel subfamily K member 2
Ligand
BDBM50101817
Substrate
n/a
Meas. Tech.
ChEMBL_1584412 (CHEMBL3819955)
IC50
8200±n/a nM
Citation
 Vivier, D; Bennis, K; Lesage, F; Ducki, S Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target? J Med Chem 59:5149-57 (2016) [PubMed]  Article 
Target
Name:
Potassium two pore domain channel subfamily K member 2
Synonyms:
Potassium channel subfamily K member 2
Type:
PROTEIN
Mol. Mass.:
45443.30
Organism:
Bos taurus
Description:
ChEMBL_620769
Residue:
411
Sequence:
MAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHACVNSTELDELIQQIVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATSIKRKLSAELAGNHNQELTPCRRTLSVNHLASERDVLPSLLKTESIYLNGLTPHCAGEEIAVIENIK
  
Inhibitor
Name:
BDBM50101817
Synonyms:
Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CHEBI:7565 | Nifedipine | Procardia | Procardia Xl
Type:
Small organic molecule
Emp. Form.:
C17H18N2O6
Mol. Mass.:
346.3346
SMILES:
COC(=O)C1=C(C)NC(C)=C(C1c1ccccc1[N+]([O-])=O)C(=O)OC |c:4,9|
Structure:
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