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Target
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
Ligand
BDBM227588
Substrate
n/a
Meas. Tech.
ChEBML_1660055
IC50
727000±n/a nM
Citation
 Liu, Y; Xie, Z; Zhao, D; Zhu, J; Mao, F; Tang, S; Xu, H; Luo, C; Geng, M; Huang, M; Li, J Development of the First Generation of Disulfide-Based Subtype-Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors. J Med Chem 60:2227-2244 (2017) [PubMed]  Article 
Target
Name:
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
Synonyms:
PDHK4 | PDK4 | PDK4_HUMAN | Pyruvate dehydrogenase kinase | Pyruvate dehydrogenase kinase 4 (PDK4) | Pyruvate dehydrogenase kinase isoform 4
Type:
Enzyme
Mol. Mass.:
46469.71
Organism:
Homo sapiens (Human)
Description:
Q16654
Residue:
411
Sequence:
MKAARFVLRSAGSLNGAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILKEIDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKALSDFVDTLIKVRNRHHNVVPTMAQGIIEYKDACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDSQTGNPSHIGSIDPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGKFPDQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIVVLGKEDLTIKISDRGGGVPLRIIDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM
  
Inhibitor
Name:
BDBM227588
Synonyms:
DCA
Type:
Small organic molecule
Emp. Form.:
C2H2Cl2O2
Mol. Mass.:
128.942
SMILES:
OC(=O)C(Cl)Cl
Structure:
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