Reaction Details Report a problem with these data
Target
Collagenase 3
Ligand
BDBM24524
Substrate
n/a
Meas. Tech.
Fluorimetric Assay
pH
7±0
Temperature
298.15±0 K
IC50
9.8e+4±n/a nM
Citation
 Panico, AM; Vicini, P; Geronikaki, A; Incerti, M; Cardile, V; Crascì, L; Messina, R; Ronsisvalle, S Heteroarylimino-4-thiazolidinones as inhibitors of cartilage degradation. Bioorg Chem 39:48-52 (2011) [PubMed]  Article 
Target
Name:
Collagenase 3
Synonyms:
MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13)
Type:
Enzyme
Mol. Mass.:
53808.06
Organism:
Homo sapiens (Human)
Description:
P45452
Residue:
471
Sequence:
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
  
Inhibitor
Name:
BDBM24524
Synonyms:
(2E,5E)-2-(1,3-benzothiazol-2-ylimino)-5-[(4-methoxyphenyl)methylidene]-1,3-thiazolidin-4-one | 2-(benzo[d]-thiazol-2-ylimino)-5-benzylidenethiazolidin-4-one, 4a | Benzothiazolyl- analogue, 11
Type:
Small organic molecule
Emp. Form.:
C18H13N3O2S2
Mol. Mass.:
367.445
SMILES:
COc1ccc(\C=C2\S\C(NC2=O)=N\c2nc3ccccc3s2)cc1
Structure:
Search PDB for entries with ligand similarity: