Reaction Details Report a problem with these data
Target
Prothrombin
Ligand
BDBM82656
Substrate
n/a
Meas. Tech.
Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay
IC50
>100000±0 nM
Citation
 PubChem, PC Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin | THRB_BOVIN | Thrombin | Thrombin heavy chain | Thrombin light chain
Type:
Enzyme
Mol. Mass.:
70502.73
Organism:
Bos taurus (Bovine)
Description:
P00735
Residue:
625
Sequence:
MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS
  
Inhibitor
Name:
BDBM82656
Synonyms:
4-bromobenzaldehyde (5-chloro-6-oxo-1-phenyl-1,6-dihydro-4-pyridazinyl)hydrazone | 5-[(N''E)-N''-(4-bromobenzylidene)hydrazino]-4-chloro-2-phenyl-pyridazin-3-one | 5-[(N'E)-N'-(4-bromobenzylidene)hydrazino]-4-chloro-2-phenyl-pyridazin-3-one | 5-[2-[(4-bromophenyl)methylidene]hydrazinyl]-4-chloranyl-2-phenyl-pyridazin-3-one | 5-[2-[(4-bromophenyl)methylidene]hydrazinyl]-4-chloro-2-phenyl-3-pyridazinone | 5-[2-[(4-bromophenyl)methylidene]hydrazinyl]-4-chloro-2-phenylpyridazin-3-one | 5-[N'-(4-bromobenzylidene)hydrazino]-4-chloro-2-phenyl-pyridazin-3-one | MLS000545718 | SMR000162973 | cid_2787935
Type:
Small organic molecule
Emp. Form.:
C17H12BrClN4O
Mol. Mass.:
403.66
SMILES:
Clc1c(cnn(-c2ccccc2)c1=O)N=NCc1ccc(Br)cc1 |w:14.15|
Structure:
Search PDB for entries with ligand similarity: