Reaction Details Report a problem with these data
Target
Xylosyl- and glucuronyltransferase LARGE1
Ligand
BDBM64296
Substrate
n/a
EC50
6990±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule activators of alpha dystroglycan glycosylation PubChem Bioassay (2012)[AID] 
Target
Name:
Xylosyl- and glucuronyltransferase LARGE1
Synonyms:
KIAA0609 | LARG1_HUMAN | LARGE | LARGE1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
88079.63
Organism:
Homo sapiens (Human)
Description:
gi_47678551
Residue:
756
Sequence:
MLGICRGRRKFLAASLSLLCIPAITWIYLFSGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRMREVEEENRALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDVQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS
  
Inhibitor
Name:
BDBM64296
Synonyms:
MLS001126583 | N-[3-(3-chlorophenyl)phenyl]-1-[(1-ethyl-3-methyl-4-pyrazolyl)methyl]-4-piperidinecarboxamide | N-[3-(3-chlorophenyl)phenyl]-1-[(1-ethyl-3-methyl-pyrazol-4-yl)methyl]isonipecotamide | N-[3-(3-chlorophenyl)phenyl]-1-[(1-ethyl-3-methyl-pyrazol-4-yl)methyl]piperidine-4-carboxamide | N-[3-(3-chlorophenyl)phenyl]-1-[(1-ethyl-3-methylpyrazol-4-yl)methyl]piperidine-4-carboxamide | SMR000671754 | cid_24792012
Type:
Small organic molecule
Emp. Form.:
C25H29ClN4O
Mol. Mass.:
436.977
SMILES:
CCn1cc(CN2CCC(CC2)C(=O)Nc2cccc(c2)-c2cccc(Cl)c2)c(C)n1
Structure:
Search PDB for entries with ligand similarity: