Reaction Details Report a problem with these data
Target
Xylosyl- and glucuronyltransferase LARGE1
Ligand
BDBM94761
Substrate
n/a
EC50
6070±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule activators of alpha dystroglycan glycosylation PubChem Bioassay (2012)[AID] 
Target
Name:
Xylosyl- and glucuronyltransferase LARGE1
Synonyms:
KIAA0609 | LARG1_HUMAN | LARGE | LARGE1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
88079.63
Organism:
Homo sapiens (Human)
Description:
gi_47678551
Residue:
756
Sequence:
MLGICRGRRKFLAASLSLLCIPAITWIYLFSGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRMREVEEENRALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDVQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS
  
Inhibitor
Name:
BDBM94761
Synonyms:
3-[1-benzothiophen-2-ylmethyl(methyl)amino]-2-ethyl-N-[1-(phenylmethyl)-4-piperidinyl]-6-imidazo[1,2-a]pyridinecarboxamide | 3-[1-benzothiophen-2-ylmethyl(methyl)amino]-2-ethyl-N-[1-(phenylmethyl)piperidin-4-yl]imidazo[1,2-a]pyridine-6-carboxamide | 3-[1-benzothiophen-2-ylmethyl(methyl)amino]-N-(1-benzylpiperidin-4-yl)-2-ethylimidazo[1,2-a]pyridine-6-carboxamide | 3-[benzothiophen-2-ylmethyl(methyl)amino]-N-(1-benzyl-4-piperidyl)-2-ethyl-imidazo[1,2-a]pyridine-6-carboxamide | MLS003121236 | SMR001283653 | cid_46942685
Type:
Small organic molecule
Emp. Form.:
C32H35N5OS
Mol. Mass.:
537.718
SMILES:
CCc1nc2ccc(cn2c1N(C)Cc1cc2ccccc2s1)C(=O)NC1CCN(Cc2ccccc2)CC1
Structure:
Search PDB for entries with ligand similarity: