Reaction Details Report a problem with these data
Target
Xylosyl- and glucuronyltransferase LARGE1
Ligand
BDBM94762
Substrate
n/a
EC50
8930±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule activators of alpha dystroglycan glycosylation PubChem Bioassay (2012)[AID] 
Target
Name:
Xylosyl- and glucuronyltransferase LARGE1
Synonyms:
KIAA0609 | LARG1_HUMAN | LARGE | LARGE1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
88079.63
Organism:
Homo sapiens (Human)
Description:
gi_47678551
Residue:
756
Sequence:
MLGICRGRRKFLAASLSLLCIPAITWIYLFSGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRMREVEEENRALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDVQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS
  
Inhibitor
Name:
BDBM94762
Synonyms:
4-[1-amino-2-(4-chlorophenyl)ethyl]-N-(4-methylsulfonylphenyl)-1,3-thiazol-2-amine | 4-[1-amino-2-(4-chlorophenyl)ethyl]-N-(4-methylsulfonylphenyl)-2-thiazolamine | 4-[1-azanyl-2-(4-chlorophenyl)ethyl]-N-(4-methylsulfonylphenyl)-1,3-thiazol-2-amine | MLS003123770 | SMR001291831 | [4-[1-amino-2-(4-chlorophenyl)ethyl]thiazol-2-yl]-(4-mesylphenyl)amine | cid_46942717
Type:
Small organic molecule
Emp. Form.:
C18H18ClN3O2S2
Mol. Mass.:
407.937
SMILES:
CS(=O)(=O)c1ccc(Nc2nc(cs2)C(N)Cc2ccc(Cl)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: