Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Xylosyl- and glucuronyltransferase LARGE1
Ligand
BDBM94769
Substrate
n/a
EC50
7970±n/a nM
Citation
PubChem, PC Dose response confirmation of small molecule activators of alpha dystroglycan glycosylation PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
Xylosyl- and glucuronyltransferase LARGE1
Synonyms:
KIAA0609 | LARG1_HUMAN | LARGE | LARGE1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
88079.63
Organism:
Homo sapiens (Human)
Description:
gi_47678551
Residue:
756
Sequence:
MLGICRGRRKFLAASLSLLCIPAITWIYLFSGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRMREVEEENRALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDVQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS
Inhibitor
Name:
BDBM94769
Synonyms:
4-[3-(cyclohexylmethyl)-2-imidazo[2,1-a]isoquinolinyl]benzonitrile | 4-[3-(cyclohexylmethyl)imidaz[2,1-a]isoquinolin-2-yl]benzonitrile | 4-[3-(cyclohexylmethyl)imidazo[2,1-a]isoquinolin-2-yl]benzenecarbonitrile | 4-[3-(cyclohexylmethyl)imidazo[2,1-a]isoquinolin-2-yl]benzonitrile | MLS003222270 | SMR001906825 | cid_53299374
Type:
Small organic molecule
Emp. Form.:
C25H23N3
Mol. Mass.:
365.4702
SMILES:
N#Cc1ccc(cc1)-c1nc2c3ccccc3ccn2c1CC1CCCCC1
Structure:
