Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM50248522
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
254±n/a nM
Citation
 Chen, D; Song, HY; Sun, ET; Yu, N; Zou, Y Benzimidazole derivatives: preparation and pharmaceutical applications US Patent  US8551988 Publication Date 10/8/2013 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50248522
Synonyms:
CHEMBL489332 | N-hydroxy-3-(2-phenethyl-1-(2-(piperidin-1-yl)ethyl)-1H-benzo[d]imidazol-5-yl)acrylamide | US10201527, Compound 67 | US10736881, Compound 67 | US8551988, 67
Type:
Small organic molecule
Emp. Form.:
C25H30N4O2
Mol. Mass.:
418.5313
SMILES:
ONC(=O)\C=C\c1ccc2n(CCN3CCCCC3)c(CCc3ccccc3)nc2c1
Structure:
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