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Target
Acetylcholinesterase
Ligand
BDBM175296
Substrate
n/a
Meas. Tech.
Acetylcholinesterase Assay
pH
7.7±n/a
IC50
4.63e+3± 5e+1 nM
Comments
extracted
Citation
 Mutahir, S; Jonczyk, J; Bajda, M; Khan, IU; Khan, MA; Ullah, N; Ashraf, M; Qurat-Ul-Ain, null; Riaz, S; Hussain, S; Yar, M Novel biphenyl bis-sulfonamides as acetyl and butyrylcholinesterase inhibitors: Synthesis, biological evaluation and molecular modeling studies. Bioorg Chem 64:13-20 (2016) [PubMed]  Article 
Target
Name:
Acetylcholinesterase
Synonyms:
ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE)
Type:
Enzyme
Mol. Mass.:
67792.70
Organism:
Homo sapiens (Human)
Description:
P22303
Residue:
614
Sequence:
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL
  
Inhibitor
Name:
BDBM175296
Synonyms:
N,N’-(biphenyl-4,4’-diyl)bis(N-hexadecylbenzenesulfonamide) (3g)
Type:
Small organic molecule
Emp. Form.:
C56H84N2O4S2
Mol. Mass.:
913.407
SMILES:
CCCCCCCCCCCCCCCCN(c1ccc(cc1)-c1ccc(cc1)N(CCCCCCCCCCCCCCCC)S(=O)(=O)c1ccccc1)S(=O)(=O)c1ccccc1
Structure:
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