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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM186127
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay
Temperature
298.15±n/a K
IC50
>100±n/a nM
Comments
extracted
Citation
 Claremon, DA; Tice, CM; Zhuang, L; Leftheris, K; Ye, Y; Singh, SB Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 US Patent  US9163012 Publication Date 10/20/2015 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM186127
Synonyms:
US9163012, 44, Isomer 1 | US9163012, 44, Isomer 2
Type:
Small organic molecule
Emp. Form.:
C21H28N4O4
Mol. Mass.:
400.4714
SMILES:
COc1cnc(nc1)C1CCN(C1)C(=O)OC1C2CC3CC1CC(C3)(C2)C(N)=O |TLB:15:16:22:24.19.20,16:17:24:22.21.20,THB:16:21:24:17.18.25,18:17:22:24.19.20,18:19:22:17.16.25,(9.31,3.36,;8.54,2.03,;7,2.03,;6.23,3.36,;4.69,3.36,;3.92,2.03,;4.69,.69,;6.23,.69,;2.38,2.03,;1.48,3.27,;.02,2.8,;.02,1.26,;1.48,.78,;-1.32,.49,;-1.32,-1.05,;-2.65,1.26,;-3.99,.49,;-3.99,-1.05,;-4.88,-2.98,;-6.09,-2.31,;-6.07,.09,;-5.31,1.26,;-6.65,.49,;-6.65,-1.05,;-7.48,-2.95,;-5.31,-1.82,;-7.98,-1.82,;-9.31,-1.05,;-7.98,-3.36,)|
Structure:
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