Reaction Details Report a problem with these data
Target
Acyl-protein thioesterase 1 [I75L,S82A,Q83P]
Ligand
BDBM207992
Substrate
n/a
Meas. Tech.
Steady-State Kinetic Assays
pH
6.5±n/a
Ki
1200±70 nM
Comments
extracted
Citation
Won, SJ; Davda, D; Labby, KJ; Hwang, SY; Pricer, R; Majmudar, JD; Armacost, KA; Rodriguez, LA; Rodriguez, CL; Chong, FS; Torossian, KA; Palakurthi, J; Hur, ES; Meagher, JL; Brooks, CL; Stuckey, JA; Martin, BR Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2). ACS Chem Biol 11:3374-3382 (2016) [PubMed] Article
More Info.:
Target
Name:
Acyl-protein thioesterase 1 [I75L,S82A,Q83P]
Synonyms:
APT1 | Acyl-protein thioesterase 1 (APT1 I75L/S82A/Q83P) | LPL1 | LYPA1_HUMAN | LYPLA1
Type:
Protein
Mol. Mass.:
24623.32
Organism:
Homo sapiens (Human)
Description:
Human APT1 with I75L/S82A/Q83P mutations
Residue:
230
Sequence:
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRPVTLNMNVAMPSWFDLIGLSPDAPEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID