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Target
Hepatocyte growth factor receptor [960-1390]
Ligand
BDBM240732
Substrate
n/a
Meas. Tech.
Kinase Homogeneous Time-Resolved Fluorescence Assay
pH
7.5±n/a
Temperature
295.15±n/a K
IC50
2±n/a nM
Comments
extracted
Citation
 Michels, M; Follmann, M; Vakalopoulos, A; Zimmermann, K; Teusch, N; Lobell, M; Bierer, D; Engel, K; Kissel, M Fluoro-substituted 3,5-dicyano-4-(1H-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine derivatives and methods of use thereof US Patent  US9422263 Publication Date 8/23/2016 
Target
Name:
Hepatocyte growth factor receptor [960-1390]
Synonyms:
MET | MET_HUMAN | Proto-oncogene c-Met
Type:
Peptide
Mol. Mass.:
48488.78
Organism:
Homo sapiens (Human)
Description:
amino acids 960-1390
Residue:
431
Sequence:
QIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS
  
Inhibitor
Name:
BDBM240732
Synonyms:
US9422263, 2 | US9422263, 3
Type:
Small organic molecule
Emp. Form.:
C17H13F2N5
Mol. Mass.:
325.3154
SMILES:
Cc1n[nH]c2ccc(cc12)C1C(C#N)=C(C)NC(C(F)F)=C1C#N |c:22,t:15|
Structure:
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