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Target
Aurora kinase B
Ligand
BDBM375282
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
550±n/a nM
Citation
 Sampson, PB; Liu, Y; Li, S; Forrest, BT; Pauls, HW; Edwards, LG; Feher, M; Patel, NK; Laufer, R Kinase inhibitors and method of treating cancer US Patent  US10358436 Publication Date 7/23/2019 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM375282
Synonyms:
US10358436, Example A6 | US9907800, Example A6
Type:
Small organic molecule
Emp. Form.:
C18H14IN3O2
Mol. Mass.:
431.2271
SMILES:
COc1ccc2NC(=O)C3(CC3c3ccc4c(I)n[nH]c4c3)c2c1
Structure:
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