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Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM318543
Substrate
n/a
Meas. Tech.
AlphaScreen Assay A2
IC50
<100±n/a nM
Citation
 Combs, AP; Sparks, RB; Maduskuie, Jr., TP; Rodgers, JD Tricyclic heterocycles as BET protein inhibitors US Patent  US10464947 Publication Date 11/5/2019 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM318543
Synonyms:
(1R)-1-[(4S)-7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2-yl]ethane-1,2-diol | US10464947, Example 89 | US11498926, Example 89 | US9624241, Example 89
Type:
Small organic molecule
Emp. Form.:
C21H20N4O4
Mol. Mass.:
392.4079
SMILES:
Cc1noc(C)c1-c1ccc2nc(C(O)CO)n3[C@H](COc1c23)c1ccccn1 |r,wD:18.26,(-1.1,-6.16,;-2.43,-5.39,;-3.9,-5.87,;-4.8,-4.62,;-3.9,-3.37,;-4.67,-2.04,;-2.43,-3.85,;-1.1,-3.08,;.23,-3.85,;1.57,-3.08,;1.57,-1.54,;2.66,-.45,;1.72,1.17,;2.49,2.5,;1.72,3.84,;4.03,2.5,;4.8,3.84,;.23,.77,;-1.1,1.54,;-2.43,.77,;-2.43,-.77,;-1.1,-1.54,;.23,-.77,;-1.1,3.08,;-2.43,3.85,;-2.43,5.39,;-1.1,6.16,;.23,5.39,;.23,3.85,)|
Structure:
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