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Target
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]
Ligand
BDBM210021
Substrate
n/a
Meas. Tech.
Raf IC50 Assay Protocol
IC50
<0.250±n/a nM
Citation
 Zhou, C; Wang, S; Zhang, G Fused tricyclic compounds as Raf kinase inhibitors US Patent  US10576087 Publication Date 3/3/2020 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]
Synonyms:
C-Raf (Y340D/Y341D) | RAF | RAF1 | RAF1_HUMAN
Type:
n/a
Mol. Mass.:
38958.87
Organism:
Homo sapiens (Human)
Description:
PV3805, from Invitrogen
Residue:
343
Sequence:
SQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM210021
Synonyms:
US10576087, Compound 2.27 | US9273046, 2.27 | US9895376, Compound 2.27
Type:
Small organic molecule
Emp. Form.:
C24H18N4O4
Mol. Mass.:
426.4241
SMILES:
Oc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Structure:
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