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Target
Apelin receptor
Ligand
BDBM447875
Substrate
n/a
Meas. Tech.
GTPγS Binding
EC50
56.0±n/a nM
Citation
 Chen, Y; Cheng, AC; Debenedetto, MV; Dransfield, PJ; Harvey, JS; Houze, J; Khakoo, AY; Lai, S; Ma, Z; Pattaropong, V; Swaminath, G; Kreiman, C; Moebius, DC; Sharma, A Triazole pyridyl compounds as agonists of the APJ receptor US Patent  US10689367 Publication Date 6/23/2020 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM447875
Synonyms:
US10689367, Example 203.0
Type:
Small organic molecule
Emp. Form.:
C22H23F3N8O5S
Mol. Mass.:
568.529
SMILES:
CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1Cc1cc(no1)C(F)(F)F)c1cnc(C)cn1 |r|
Structure:
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