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Target
Lysyl oxidase homolog 2
Ligand
BDBM469489
Substrate
n/a
Meas. Tech.
Amine Oxidase Activity Assay
IC50
<300±n/a nM
Citation
 Rowbottom, MW; Hutchinson, JH; Calderon, I Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof US Patent  US11072585 Publication Date 7/27/2021 
Target
Name:
Lysyl oxidase homolog 2
Synonyms:
1.4.3.13 | LOXL2 | LOXL2_HUMAN | Lysyl oxidase homolog 2 | Lysyl oxidase-like protein 2 | Lysyl oxidase-related protein 2 | Lysyl oxidase-related protein WS9-14
Type:
PROTEIN
Mol. Mass.:
86721.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_115990
Residue:
774
Sequence:
MERPLCSHLCSCLAMLALLSPLSLAQYDSWPHYPEYFQQPAPEYHQPQAPANVAKIQLRLAGQKRKHSEGRVEVYYDGQWGTVCDDDFSIHAAHVVCRELGYVEAKSWTASSSYGKGEGPIWLDNLHCTGNEATLAACTSNGWGVTDCKHTEDVGVVCSDKRIPGFKFDNSLINQIENLNIQVEDIRIRAILSTYRKRTPVMEGYVEVKEGKTWKQICDKHWTAKNSRVVCGMFGFPGERTYNTKVYKMFASRRKQRYWPFSMDCTGTEAHISSCKLGPQVSLDPMKNVTCENGLPAVVSCVPGQVFSPDGPSRFRKAYKPEQPLVRLRGGAYIGEGRVEVLKNGEWGTVCDDKWDLVSASVVCRELGFGSAKEAVTGSRLGQGIGPIHLNEIQCTGNEKSIIDCKFNAESQGCNHEEDAGVRCNTPAMGLQKKLRLNGGRNPYEGRVEVLVERNGSLVWGMVCGQNWGIVEAMVVCRQLGLGFASNAFQETWYWHGDVNSNKVVMSGVKCSGTELSLAHCRHDGEDVACPQGGVQYGAGVACSETAPDLVLNAEMVQQTTYLEDRPMFMLQCAMEENCLSASAAQTDPTTGYRRLLRFSSQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLEDTECEGDIQKNYECANFGDQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNFEVAESDYSNNIMKCRSRYDGHRIWMYNCHIGGSFSEETEKKFEHFSGLLNNQLSPQ
  
Inhibitor
Name:
BDBM469489
Synonyms:
Compound 1-11 | US11072585, Example 4
Type:
Small organic molecule
Emp. Form.:
C23H20F3N3O2
Mol. Mass.:
427.419
SMILES:
NCc1cc(Oc2cccc(c2)C(=O)N2CCc3ccccc3C2)nc(c1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: