Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50042659
Substrate
n/a
Meas. Tech.
In Vitro Assay
EC50
2.80±n/a nM
Citation
 Riether, D; Binder, FP; Doods, H; Mueller, SG; Nicholson, JR; Sauer, A (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles US Patent  US11084810 Publication Date 8/10/2021 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50042659
Synonyms:
CHEMBL3353870 | Example 190 in WO2010077836 | US10570125, Example 190 | US11084810, Example 190 in WO2010077836 | US11725004, Example 190 in WO2010077836
Type:
Small organic molecule
Emp. Form.:
C17H27N3O3
Mol. Mass.:
321.4146
SMILES:
CC(C)(C)c1cc(NC(=O)[C@@H]2CCCN2C2CCOCC2)on1 |r|
Structure:
Search PDB for entries with ligand similarity: