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Target
Bromodomain-containing protein 4 [75-147]
Ligand
BDBM343472
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
550±n/a nM
Citation
 Rodgers, JD; Shepard, S; Wang, H; Shao, L Tricyclic heterocycles as BET protein inhibitors US Patent  US11091484 Publication Date 8/17/2021 
Target
Name:
Bromodomain-containing protein 4 [75-147]
Synonyms:
BRD4 | BRD4_HUMAN | Bromo domain 1 | Bromodomain-containing protein 4 (BD1) | Bromodomain-containing protein 4 (BRD4) Bromo 1 | Bromodomain-containing protein 4 (BRD4)(BD1) | Bromodomain-containing protein 4 (BRD4)(Bromo 1) | Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) | Bromodomain-containing protein 4 Bromodomain 1 (BRD4-1) | Bromodomain-containing protein 4 Domain 1 | HUNK1
Type:
n/a
Mol. Mass.:
8856.55
Organism:
Homo sapiens (Human)
Description:
BD1 (75-147 aa) of O60885
Residue:
73
Sequence:
WKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIV
  
Inhibitor
Name:
BDBM343472
Synonyms:
US10442803, Example 71 | US11091484, Example 71 | US9777003, Example 71
Type:
Small organic molecule
Emp. Form.:
C20H18N6
Mol. Mass.:
342.3971
SMILES:
Cc1nnc2ccc3n(Cc4ccccc4)c(cc3n12)-c1cncn1C
Structure:
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