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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM376733
Substrate
n/a
Meas. Tech.
Pim Enzyme Assays
IC50
<10±n/a nM
Citation
 Vechorkin, O; Li, Y; Sokolsky, A; Wang, A; Zhu, W; Zhuo, J Heterocyclic compounds useful as Pim kinase inhibitors US Patent  US11053215 Publication Date 7/6/2021 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM376733
Synonyms:
N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(3-methyl-1H-pyrazol-4-yl)quinoline-8-carboxamide | US10450296, Example 65 | US11053215, Example 65 | US9920032, Example 65
Type:
Small organic molecule
Emp. Form.:
C26H27FN6O
Mol. Mass.:
458.5306
SMILES:
C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)-c1c[nH]nc1C |r|
Structure:
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