Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM516748
Substrate
n/a
Meas. Tech.
Human Factor D Assay
IC50
<1000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Chen, D; Gadhachanda, VR; Barrish, JC; Agarwal, A; Eastman, KJ Macrocyclic compounds for treatment of medical disorders US Patent  US11053253 Publication Date 7/6/2021 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM516748
Synonyms:
US11053253, Cmp No. T-170 | US11718626, Compound T-170
Type:
Small organic molecule
Emp. Form.:
C35H37BrFN9O5
Mol. Mass.:
762.628
SMILES:
CC(=O)c1nn(CC(=O)N2C[C@]3(F)C[C@H]2C(=O)Nc2nc(Br)ccc2COC\C=C/CC(C)(C)C(=O)NC3)c2cnc(cc12)-c1cnc(C)nc1 |r,w:30.31,c:30|
Structure:
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