Reaction Details Report a problem with these data
Target
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
Ligand
BDBM518926
Substrate
n/a
Meas. Tech.
TarO Biochemical Enzymatic Assay
IC50
0.000±n/a nM
Citation
Caldwell, JP; Ho, GD; Ha, SN; Koseoglu, SJ; Labroli, MA; Lee, SH; Madsen-Duggan, C; Mandal, M; Pan, J; Pan, W; Roemer, T; Su, J; Tan, CM; Tan, Z; Wang, H; Yang, C; Yang, S Benzimidazoles and indoles as taro inhibitors US Patent US11141403 Publication Date 10/12/2021
More Info.:
Target
Name:
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
Synonyms:
GNPTA | GNPTAB | GNPTA_HUMAN | GlcNAc-1-phosphotransferase subunits alpha/beta | KIAA1208 | Stealth protein GNPTAB | UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
Type:
Protein
Mol. Mass.:
143634.29
Organism:
Human
Description:
Q3T906
Residue:
1256
Sequence:
MLFKLLQRQTYTCLSHRYGLYVCFLGVVVTIVSAFQFGEVVLEWSRDQYHVLFDSYRDNIAGKSFQNRLCLPMPIDVVYTWVNGTDLELLKELQQVREQMEEEQKAMREILGKNTTEPTKKSEKQLECLLTHCIKVPMLVLDPALPANITLKDLPSLYPSFHSASDIFNVAKPKNPSTNVSVVVFDSTKDVEDAHSGLLKGNSRQTVWRGYLTTDKEVPGLVLMQDLAFLSGFPPTFKETNQLKTKLPENLSSKVKLLQLYSEASVALLKLNNPKDFQELNKQTKKNMTIDGKELTISPAYLLWDLSAISQSKQDEDISASRFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNLDNPRVTIVTHQDVFRNLSHLPTFSSPAIESHIHRIEGLSQKFIYLNDDVMFGKDVWPDDFYSHSKGQKVYLTWPVPNCAEGCPGSWIKDGYCDKACNNSACDWDGGDCSGNSGGSRYIAGGGGTGSIGVGQPWQFGGGINSVSYCNQGCANSWLADKFCDQACNVLSCGFDAGDCGQDHFHELYKVILLPNQTHYIIPKGECLPYFSFAEVAKRGVEGAYSDNPIIRHASIANKWKTIHLIMHSGMNATTIHFNLTFQNTNDEEFKMQITVEVDTREGPKLNSTAQKGYENLVSPITLLPEAEILFEDIPKEKRFPKFKRHDVNSTRRAQEEVKIPLVNISLLPKDAQLSLNTLDLQLEHGDITLKGYNLSKSALLRSFLMNSQHAKIKNQAIITDETNDSLVAPQEKQVHKSILPNSLGVSERLQRLTFPAVSVKVNGHDQGQNPPLDLETTARFRVETHTQKTIGGNVTKEKPPSLIVPLESQMTKEKKITGKEKENSRMEENAENHIGVTEVLLGRKLQHYTDSYLGFLPWEKKKYFQDLLDEEESLKTQLAYFTDSKNTGRQLKDTFADSLRYVNKILNSKFGFTSRKVPAHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMSAVQPLNISQVFDEVDTDQSGVLSDREIRTLATRIHELPLSLQDLTGLEHMLINCSKMLPADITQLNNIPPTQESYYDPNLPPVTKSLVTNCKPVTDKIHKAYKDKNKYRFEIMGEEEIAFKMIRTNVSHVVGQLDDIRKNPRKFVCLNDNIDHNHKDAQTVKAVLRDFYESMFPIPSQFELPREYRNRFLHMHELQEWRAYRDKLKFWTHCVLATLIMFTIFSFFAEQLIALKRKIFPRRRIHKEASPNRIRV
Inhibitor
Name:
BDBM518926
Synonyms:
N-cyclohexyl-N-ethyl-3-(2-(trans-4-ethylcyclohexyl)-6-phenyl-1H-benzo[d]imidazol-1-yl)propanamide | US11141403, Example 24
Type:
Small organic molecule
Emp. Form.:
C32H43N3O
Mol. Mass.:
485.7033
SMILES:
CC[C@H]1CC[C@@H](CC1)c1nc2ccc(cc2n1CCC(=O)N(CC)C1CCCCC1)-c1ccccc1 |r,wU:2.1,wD:5.8,(-7.98,-5.3,;-7.21,-3.97,;-5.67,-3.97,;-4.9,-2.64,;-3.36,-2.64,;-2.59,-3.97,;-3.36,-5.3,;-4.9,-5.3,;-1.05,-3.97,;-.15,-5.22,;1.32,-4.74,;2.65,-5.51,;3.98,-4.74,;3.98,-3.2,;2.65,-2.43,;1.32,-3.2,;-.15,-2.72,;-.55,-1.24,;-2.04,-.84,;-2.43,.65,;-1.34,1.74,;-3.92,1.05,;-5.01,-.04,;-6.5,.36,;-4.32,2.54,;-3.23,3.62,;-3.63,5.11,;-5.12,5.51,;-6.21,4.42,;-5.81,2.93,;5.32,-2.43,;6.65,-3.2,;7.98,-2.43,;7.98,-.89,;6.65,-.12,;5.32,-.89,)|