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Target
Monoglyceride lipase
Ligand
BDBM519817
Substrate
n/a
Meas. Tech.
Preparation of Mouse Brain Proteomes from Inhibitor Treated Mice
IC50
<100±n/a nM
Citation
 Grice, CA; Weber, OD; Buzard, DJ; Shaghafi, MB; Jones, TK Spirocycle compounds and methods of making and using same US Patent  US11142526 Publication Date 10/12/2021 
Target
Name:
Monoglyceride lipase
Synonyms:
MAG lipase | MGLL_MOUSE | Mgll | Monoacylglycerol lipase | Monoglyceride Lipase (MGL)
Type:
Hydrolase
Mol. Mass.:
33391.67
Organism:
Mus musculus (mouse)
Description:
Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells.
Residue:
303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLGHSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRIDSSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP
  
Inhibitor
Name:
BDBM519817
Synonyms:
1,1,1,3,3,3- Hexafluoropropan- 2-yl 1-((3- chlorobenzo[b] thiophen-2- yl)methyl)-1,8- diazaspiro[4.5] decane-8- carboxylate | US11142526, Example 42
Type:
Small organic molecule
Emp. Form.:
C21H21ClF6N2O2S
Mol. Mass.:
514.912
SMILES:
FC(F)(F)C(OC(=O)N1CCC2(CCCN2Cc2sc3ccccc3c2Cl)CC1)C(F)(F)F
Structure:
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