Reaction Details Report a problem with these data
Target
C5a anaphylatoxin chemotactic receptor 1
Ligand
BDBM520690
Substrate
n/a
Meas. Tech.
Calcium++ Mobilization Assay
IC50
550±n/a nM
Citation
 Li, Y; Guo, R; Riedemann, NC Fused piperidinyl bicyclic and related compounds as modulators of C5A receptor US Patent  US11149009 Publication Date 10/19/2021 
Target
Name:
C5a anaphylatoxin chemotactic receptor 1
Synonyms:
C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88
Type:
Enzyme
Mol. Mass.:
39347.68
Organism:
Homo sapiens (Human)
Description:
P21730
Residue:
350
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
  
Inhibitor
Name:
BDBM520690
Synonyms:
US11149009, Compound INF040
Type:
Small organic molecule
Emp. Form.:
C37H36F3N3O3
Mol. Mass.:
627.6952
SMILES:
Cc1ccccc1C(=O)N1[C@H]([C@H](Cc2ccccc12)C(=O)Nc1ccc(CO)c(c1)C(F)(F)F)c1ccc(NC2CCCC2)cc1 |r|
Structure:
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