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Target
Bone morphogenetic protein receptor type-1B [168-495]
Ligand
BDBM522144
Substrate
n/a
Meas. Tech.
In Vitro Enzyme Inhibition Using a Biochemical Peptide Phosphorylation Assay- Caliper Assay
IC50
4700±n/a nM
Citation
 Arista, L; Chamoin, S; D''Alessandro, PL; Lindvall, M; Lizos, D; Stiefl, NJ; Teixeira-Fouchard, S; Ullrich, T; Weiler, S Pyridinone derivatives and their use as selective ALK-2 inhibitors US Patent  US11160797 Publication Date 11/2/2021 
Target
Name:
Bone morphogenetic protein receptor type-1B [168-495]
Synonyms:
BMPR1B | BMR1B_HUMAN | Bone morphogenetic protein receptor type-1B (BMPR1B) aa 168-495
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37241.56
Organism:
Homo sapiens (Human)
Description:
O00238[168-495]
Residue:
328
Sequence:
TYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMS
  
Inhibitor
Name:
BDBM522144
Synonyms:
US11160797, Example 52
Type:
Small organic molecule
Emp. Form.:
C22H20FN3O2
Mol. Mass.:
377.4115
SMILES:
CC(C)n1cc(ccc1=O)-c1cncc(-c2ccc3N(C)C(=O)Cc3c2)c1F
Structure:
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