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Target
Tyrosine-protein kinase JAK2 [828-1132]
Ligand
BDBM344061
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
>2000±n/a nM
Citation
 Li, Y; Zhu, W; Mei, S; Glenn, J Tricyclic fused thiophene derivatives as JAK inhibitors US Patent  US11161855 Publication Date 11/2/2021 
Target
Name:
Tyrosine-protein kinase JAK2 [828-1132]
Synonyms:
JAK2 | JAK2_HUMAN | Tyrosine-protein kinase JAK2 (aa 828-1132)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35522.23
Organism:
Homo sapiens (Human)
Description:
aa 828-1132
Residue:
304
Sequence:
ALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM344061
Synonyms:
US10370387, Example 45 | US10479803, Example 1C | US11161855, Example 45 | US9777017, Example 45 | US9908895, Example 45
Type:
Small organic molecule
Emp. Form.:
C17H18N4O2S
Mol. Mass.:
342.415
SMILES:
C[C@H](O)c1nc2cnc3ccsc3c2n1[C@H]1CC[C@H](CC#N)OC1 |r|
Structure:
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