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Target
Stimulator of interferon genes protein [154-378]
Ligand
BDBM523221
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
<1000±n/a nM
Citation
 Diller, DJ; Metzger, A; Kaelin, Jr., DE; Paget, S; Huang, C; Mcguinness, BF; Hospital, AJ; Solvibile, Jr., WR Sting agonists US Patent  US11161864 Publication Date 11/2/2021 
Target
Name:
Stimulator of interferon genes protein [154-378]
Synonyms:
Eris | Mita | Mpys | STING_MOUSE | Stimulator of interferon genes protein (Sting1)(154-378) | Sting | Sting1 | Tmem173
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25501.41
Organism:
Mus musculus (Mouse)
Description:
aa 154-378
Residue:
225
Sequence:
VAHGLAWSYYIGYLRLILPGLQARIRMFNQLHNNMLSGAGSRRLYILFPLDCGVPDNLSVVDPNIRFRDMLPQQNIDRAGIKNRVYSNSVYEILENGQPAGVCILEYATPLQTLFAMSQDAKAGFSREDRLEQAKLFCRTLEEILEDVPESRNNCRLIVYQEPTDGNSFSLSQEVLRHIRQEEKEEVTMNAPMTSVAPPPSVLSQEPRLLISGMDQPLPLRTDLI
  
Inhibitor
Name:
BDBM523221
Synonyms:
US11161864, Example 37A | US11161864, Example 37B
Type:
Small organic molecule
Emp. Form.:
C20H22FN9O9P2S2
Mol. Mass.:
677.52
SMILES:
NC(=O)c1cnc2n3CCOP(S)(=O)OC[C@H]4O[C@H]([C@H](OP(S)(=O)OCc3nc2c1)[C@@H]4F)n1cnc2c1nc(N)[nH]c2=O |r|
Structure:
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