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Target
Stimulator of interferon genes protein [155-379]
Ligand
BDBM523223
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
<1000±n/a nM
Citation
 Diller, DJ; Metzger, A; Kaelin, Jr., DE; Paget, S; Huang, C; Mcguinness, BF; Hospital, AJ; Solvibile, Jr., WR Sting agonists US Patent  US11161864 Publication Date 11/2/2021 
Target
Name:
Stimulator of interferon genes protein [155-379]
Synonyms:
ERIS | MITA | STING | STING1 | STING_HUMAN | Stimulator of interferon genes protein (STING1)(AQ)(155-379) | TMEM173
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25427.39
Organism:
Homo sapiens (Human)
Description:
aa 155-379
Residue:
225
Sequence:
VAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM523223
Synonyms:
US11161864, Example 38A | US11161864, Example 38B | US11161864, Example 38C | US11161864, Example 38D
Type:
Small organic molecule
Emp. Form.:
C20H20FN9O8P2S2
Mol. Mass.:
659.504
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2COP(S)(=O)OCCn3c(COP(S)(=O)O[C@@H]1[C@@H]2F)nc1cc(cnc31)C#N |r|
Structure:
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