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Target
Stimulator of interferon genes protein
Ligand
BDBM523227
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
<1000±n/a nM
Citation
 Diller, DJ; Metzger, A; Kaelin, Jr., DE; Paget, S; Huang, C; Mcguinness, BF; Hospital, AJ; Solvibile, Jr., WR Sting agonists US Patent  US11161864 Publication Date 11/2/2021 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING
Type:
Protein
Mol. Mass.:
42195.64
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM523227
Synonyms:
US11161864, Example 39
Type:
Small organic molecule
Emp. Form.:
C18H20FN9O7P2S3
Mol. Mass.:
651.548
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2COP(S)(=S)OCCn3c(COP(S)(=O)O[C@@H]1[C@@H]2F)nc1cncnc31 |r|
Structure:
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