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Target
Luciferin 4-monooxygenase
Ligand
BDBM526447
Substrate
n/a
Meas. Tech.
YAP Reporter Assay
IC50
<100±n/a nM
Citation
 Konradi, AW; Lin, TT Non-fused tricyclic compounds US Patent  US11186554 Publication Date 11/30/2021 
Target
Name:
Luciferin 4-monooxygenase
Synonyms:
LUCI_LUCMI | Luciferase
Type:
Protein
Mol. Mass.:
60495.67
Organism:
Southern Russian firefly
Description:
Q26304
Residue:
548
Sequence:
MEMEKEENVVYGPLPFYPIEEGSAGIQLHKYMHQYAKLGAIAFSNALTGVDISYQEYFDITCRLAEAMKNFGMKPEEHIALCSENCEEFFIPVLAGLYIGVAVAPTNEIYTLRELNHSLGIAQPTIVFSSRKGLPKVLEVQKTVTCIKKIVILDSKVNFGGHDCMETFIKKHVELGFQPSSFVPIDVKNRKQHVALLMNSSGSTGLPKGVRITHEGAVTRFSHAKDPIYGNQVSPGTAILTVVPFHHGFGMFTTLGYFACGYRVVMLTKFDEELFLRTLQDYKCTSVILVPTLFAILNKSELIDKFDLSNLTEIASGGAPLAKEVGEAVARRFNLPGVRQGYGLTETTSAFIITPEGDDKPGASGKVVPLFKVKVIDLDTKKTLGVNRRGEICVKGPSLMLGYSNNPEATRETIDEEGWLHTGDIGYYDEDEHFFIVDRLKSLIKYKGYQVPPAELESVLLQHPNIFDAGVAGVPDPDAGELPGAVVVMEKGKTMTEKEIVDYVNSQVVNHKRLRGGVRFVDEVPKGLTGKIDAKVIREILKKPQAKM
  
Inhibitor
Name:
BDBM526447
Synonyms:
3-[[5-[2-[4- (trifluoromethyl)anilino]phenyl]tetrazol-2- yl]methyl]thietan-3-ol | US11186554, Compound 244
Type:
Small organic molecule
Emp. Form.:
C18H16F3N5OS
Mol. Mass.:
407.413
SMILES:
OC1(Cn2nnc(n2)-c2ccccc2Nc2ccc(cc2)C(F)(F)F)CSC1
Structure:
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