Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase JAK1 [837-1142]
Ligand
BDBM314690
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
<10±n/a nM
Citation
 Yao, W; Burns, DM; Zhuo, J Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors US Patent  US11214573 Publication Date 1/4/2022 
Target
Name:
Tyrosine-protein kinase JAK1 [837-1142]
Synonyms:
JAK1 | JAK1 (aa 837-1142) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (837-1142) | Tyrosine-protein kinase JAK1 (aa 837-1142)
Type:
n/a
Mol. Mass.:
35230.04
Organism:
Homo sapiens (Human)
Description:
P23458[837-1142]
Residue:
306
Sequence:
FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSF
  
Inhibitor
Name:
BDBM314690
Synonyms:
US10513522, Example 27 | US11214573, Example 3 | US9611269, Example 3
Type:
Small organic molecule
Emp. Form.:
C24H23FN8O
Mol. Mass.:
458.4908
SMILES:
CC(C)NC(=O)c1ccc(N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(F)c1
Structure:
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