Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase JAK2 [828-1132]
Ligand
BDBM314690
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
<10±n/a nM
Citation
 Yao, W; Burns, DM; Zhuo, J Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors US Patent  US11214573 Publication Date 1/4/2022 
Target
Name:
Tyrosine-protein kinase JAK2 [828-1132]
Synonyms:
JAK2 | JAK2 (aa 828-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2
Type:
n/a
Mol. Mass.:
35579.28
Organism:
Homo sapiens (Human)
Description:
O60674[828-1132]
Residue:
305
Sequence:
GALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM314690
Synonyms:
US10513522, Example 27 | US11214573, Example 3 | US9611269, Example 3
Type:
Small organic molecule
Emp. Form.:
C24H23FN8O
Mol. Mass.:
458.4908
SMILES:
CC(C)NC(=O)c1ccc(N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(F)c1
Structure:
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