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Target
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
Ligand
BDBM50345745
Substrate
n/a
Meas. Tech.
KinaseGlo Assay
IC50
110±n/a nM
Citation
 Van Voorhis, WC; Hol, WG; Larson, ET; Maly, DJ; Merritt, E; Ojo, KK Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases US Patent  US11247972 Publication Date 2/15/2022 
Target
Name:
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
Synonyms:
cGMP-dependent protein kinase (CpCDPK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
80612.61
Organism:
Cryptosporidium parvum (strain Iowa II)
Description:
Q5CTY5
Residue:
718
Sequence:
MMGQGQNALNGVCSRRYEKDSIEINKNKEVRRKQSNKRGNFPAHNMTHGKPEYLKEAVDRLINHGNIVGNSPDRYLAKERKSQASCSTSDPTSPLAYRNGNDNYFEQYEICDLIELTSEMALSNESRFESLSEYESIPKLSPSTTVMGITDVSATNTSNSNSATPTESEKGSGPKLSLTEGKFRREGLIPACKGSIHSDYIIDSGRIGKGTYGSVKSGTNRLTGCIRAIKTIPLTRVEALDNFMKEINILKNLDHPNIVKLYETYQDKENIYLVMELCSGGELFDRIISQGSFDEIYAANLMKQVLSTICYCHDHGIVHRDLKPENFLFLNKNYNAPLKIIDFGLAARVNNEDTSLNTRAGTPYYVAPEVLQGKYDKQCDMWSLGVILYILLCGYPPFHGSNDSIILHKVQKGVYAFKEEDWKHVSFLAIDLIRKLLTYNPSERITARDALNHPWITRFADDILFLSPRNYFYSNDGFMKTGIVSSDYIDSSINNLKALECQQKPRNCNLMGSRRNGYIKGGLRYCRSKRRSISSSSGLNLLSNFRAFHKYNRFMKVALTVIAQQMTESQISNLKEAFILLDANCDGTLTPQEIITGLKNSGITELPSDLLAILNDIDSDGSGSIDYTEFIAATLDSKQYSKEQVCWAAFKVFDQDGNGKITANELLNVFSYNSEQGSAGINDKALSDVKNMIKEVDVDGDGEIDFQEFLEMFRRSNS
  
Inhibitor
Name:
BDBM50345745
Synonyms:
3-(chroman-6-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | CHEMBL1785024 | US10544104, Compound 7w | US11247972, Compound 7w | US9765037, Compound 7w
Type:
Small organic molecule
Emp. Form.:
C17H19N5O
Mol. Mass.:
309.3657
SMILES:
CC(C)n1nc(-c2ccc3OCCCc3c2)c2c(N)ncnc12
Structure:
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