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Target
Tyrosine-protein kinase JAK1 [837-1142]
Ligand
BDBM400386
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
12.5±n/a nM
Citation
 Huang, T; Xue, C Piperidin-4-yl azetidine derivatives as JAK1 inhibitors US Patent  US11285140 Publication Date 3/29/2022 
Target
Name:
Tyrosine-protein kinase JAK1 [837-1142]
Synonyms:
JAK1 | JAK1 (aa 837-1142) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (837-1142) | Tyrosine-protein kinase JAK1 (aa 837-1142)
Type:
n/a
Mol. Mass.:
35230.04
Organism:
Homo sapiens (Human)
Description:
P23458[837-1142]
Residue:
306
Sequence:
FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSF
  
Inhibitor
Name:
BDBM400386
Synonyms:
US10695337, Example 140 | US11285140, Example 140 | US9999619, Example 141
Type:
Small organic molecule
Emp. Form.:
C29H26FN9O
Mol. Mass.:
535.5748
SMILES:
Fc1cc(ccc1C#N)C(=O)N1C2CCC1CC(C2)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 |THB:19:17:13.14:11|
Structure:
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