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Target
Tyrosine-protein kinase JAK2 [828-1132]
Ligand
BDBM400483
Substrate
n/a
IC50
30±n/a nM
Citation
 Huang, T; Xue, C Piperidin-4-yl azetidine derivatives as JAK1 inhibitors US Patent  US11285140 Publication Date 3/29/2022 
Target
Name:
Tyrosine-protein kinase JAK2 [828-1132]
Synonyms:
JAK2 | JAK2 (aa 828-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2
Type:
n/a
Mol. Mass.:
35579.28
Organism:
Homo sapiens (Human)
Description:
O60674[828-1132]
Residue:
305
Sequence:
GALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM400483
Synonyms:
US10695337, Example 238 | US11285140, Example 238 | US9999619, Example 238
Type:
Small organic molecule
Emp. Form.:
C30H30ClN9O
Mol. Mass.:
568.072
SMILES:
COc1ccc2nc(Cl)c(CN3CCC(CC3)N3CC(CC#N)(C3)n3cc(cn3)-c3ncnc4[nH]ccc34)cc2c1
Structure:
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