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Target
Monocarboxylate transporter 4
Ligand
BDBM345286
Substrate
n/a
Meas. Tech.
Biological Activity Assay 3
IC50
79.0±n/a nM
Citation
 Parnell, KM; McCall, J; Romero, D Heterocyclic inhibitors of MCT4 US Patent  US11292767 Publication Date 4/5/2022 
Target
Name:
Monocarboxylate transporter 4
Synonyms:
MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3
Type:
PROTEIN
Mol. Mass.:
49474.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104604
Residue:
465
Sequence:
MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
  
Inhibitor
Name:
BDBM345286
Synonyms:
2-[[5-(3-Methoxyphenyl)-1-(o- tolylmethyl)pyrazol-3-yl]methoxy]-2- methyl-propanoic acid. 1HNMR (CDCl3): $#948; 1.55 (s, 6H), 2.18 (s, 3H), 3.64 (s, 3H), 4.62 9s, 2H), 5.31 (s, 2H), 6.38 (s, 1H), 6.69-6.31 (m, 1H), 6.77- 6.78 (m, 1H), 6.86-6.92 (m, 2H), 7.10-7.15 (m, 3H), 7.25-7.29 (m, 1H). | US10202350, Example 32 | US10214492, Example 32 | US11292767, Example 32 | US11724989, Example 32
Type:
Small organic molecule
Emp. Form.:
C23H26N2O4
Mol. Mass.:
394.4635
SMILES:
COc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1C
Structure:
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