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Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM556286
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
0.600±n/a nM
Citation
 Rai, R; Booth, R; Green, MJ PGDH inhibitors and methods of making and using US Patent  US11345702 Publication Date 5/31/2022 
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM556286
Synonyms:
US11345702, Table 1.4 | US20230390274, Compound A-45
Type:
Small organic molecule
Emp. Form.:
C17H17N5O
Mol. Mass.:
307.3498
SMILES:
O=C(N1CCCCC1)c1cnc2n(ccc2c1)-c1cnccn1
Structure:
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