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Target
Nociceptin receptor
Ligand
BDBM558088
Substrate
n/a
Meas. Tech.
Cell-Based NOP Assay
Ki
>1000±n/a nM
Citation
 Thompson, JB; Bookser, BC; Burley, S; Garcia-Reynaga, P; Hudson, A; Peters, M; Pratt, B; Thompson, A; Tran, J; Valdez, L Substituted cyclohexyl compounds as NOP inhibiiors US Patent  US11365191 Publication Date 6/21/2022 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM558088
Synonyms:
US11365191, Example 173
Type:
Small organic molecule
Emp. Form.:
C20H30ClN3O
Mol. Mass.:
363.925
SMILES:
CC(=O)N1CCC(CC1)NCCC1CCC(CC1)c1ncccc1Cl |(7.34,1.92,;7.34,.38,;8.67,-.38,;6,-.39,;6,-1.93,;4.67,-2.7,;3.33,-1.93,;3.33,-.39,;4.67,.38,;2,-2.7,;.67,-1.93,;-.67,-2.7,;-2,-1.93,;-3.33,-2.69,;-4.67,-1.93,;-4.67,-.39,;-3.33,.38,;-2,-.39,;-6,.38,;-6,1.92,;-7.34,2.7,;-8.67,1.92,;-8.67,.38,;-7.34,-.39,;-7.34,-1.93,)|
Structure:
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