Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM559414
Substrate
n/a
Meas. Tech.
Factor D Esterolytic Assay
IC50
<1000±n/a nM
Citation
 Kotian, PL; Babu, YS; Zhang, W; Lu, P; Wu, M; Lv, W; Nguyen, TX; Dang, Z; Chintareddy, VR; Kumar, VS; Raman, K Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors US Patent  US11370774 Publication Date 6/28/2022 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM559414
Synonyms:
US11370774, Compound 515c
Type:
Small organic molecule
Emp. Form.:
C27H27FN2O5
Mol. Mass.:
478.5121
SMILES:
CCOC(=O)Cc1ccc(F)cc1OCc1cc(-c2ccnc(CN)c2)c2oc(COC)cc2c1
Structure:
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