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Target
Mitogen-activated protein kinase 6
Ligand
BDBM365174
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
6.36±n/a nM
Citation
 Kolesnikov, A; Do, S Serine/threonine kinase inhibitors US Patent  US11376260 Publication Date 7/5/2022 
Target
Name:
Mitogen-activated protein kinase 6
Synonyms:
ERK3 | MAPK6 | MK06_HUMAN | PRKM6
Type:
PROTEIN
Mol. Mass.:
82643.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774367
Residue:
721
Sequence:
MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYSTEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKEKSDKKGKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQHEPTDVVDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSGGEDCFFINQFCEVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERGHEEGFLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSILKHLN
  
Inhibitor
Name:
BDBM365174
Synonyms:
4-(3-(3-chlorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1- triazaacenaphthylen-7-yl)-N- (1-methyl-1H-pyrazol-5- yl)pyrimidin-2-amine | US10278975, Compound I-88 S | US11376260, Example I-88S | US9867833, Compound I-88(R)
Type:
Small organic molecule
Emp. Form.:
C23H19ClN8O
Mol. Mass.:
458.903
SMILES:
Cn1nccc1Nc1nccc(n1)-c1cc2OC[C@@H](Cc3cccc(Cl)c3)c3nnc(c1)n23 |r|
Structure:
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