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Target
Mitogen-activated protein kinase 13
Ligand
BDBM563647
Substrate
n/a
Meas. Tech.
MAPK13 and MAPK14 enzyme assays
IC50
6.00±n/a nM
Citation
 Holtzman, MJ; Romero, AG; Gerovac, BJ; Han, Z; Keeler, SP; Wu, K Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof US Patent  US11407771 Publication Date 8/9/2022 
Target
Name:
Mitogen-activated protein kinase 13
Synonyms:
MAP kinase p38 delta | MAPK13 | MK13_HUMAN | Mitogen-activated protein kinase 13 | Mitogen-activated protein kinase 13 (MAPK13) | Mitogen-activated protein kinase p38 | Mitogen-activated protein kinase p38 delta | PRKM13 | SAPK4 | Stress-activated protein kinase 4 | p38 delta/gamma
Type:
Enzyme
Mol. Mass.:
42097.16
Organism:
Homo sapiens (Human)
Description:
O15264
Residue:
365
Sequence:
MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIARKDSRRRSGMKL
  
Inhibitor
Name:
BDBM563647
Synonyms:
N-(4-{4-[3-(5-tert-Butyl-2- methyl-2H-pyrazol-3-yl)-ureido]- 3-fluoro-phenoxy}-pyridin-2-yl)- acetamide | US11407771, Compound 391
Type:
Small organic molecule
Emp. Form.:
C22H25FN6O3
Mol. Mass.:
440.4707
SMILES:
CC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(nn3C)C(C)(C)C)c(F)c2)ccn1
Structure:
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