Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 14
Ligand
BDBM563650
Substrate
n/a
Meas. Tech.
MAPK13 and MAPK14 enzyme assays
IC50
4.00±n/a nM
Citation
 Holtzman, MJ; Romero, AG; Gerovac, BJ; Han, Z; Keeler, SP; Wu, K Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof US Patent  US11407771 Publication Date 8/9/2022 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM563650
Synonyms:
N-(4-{4-[3-(3-tert-Butyl-isoxazol- 5-yl)-ureido]-3-fluoro-phenoxy}- pyridin-2-yl)-acetamide | US11407771, Compound 395
Type:
Small organic molecule
Emp. Form.:
C21H22FN5O4
Mol. Mass.:
427.4289
SMILES:
CC(=O)Nc1cc(Oc2ccc(NC(=O)Nc3cc(no3)C(C)(C)C)c(F)c2)ccn1
Structure:
Search PDB for entries with ligand similarity: