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Target
Cyclin-dependent kinase 9
Ligand
BDBM307817
Substrate
n/a
Meas. Tech.
TR-FRET Kinase Assay
IC50
22.0±n/a nM
Citation
 Mastracchio, A; Bruncko, M; Lai, C; Miyashiro, JM; Tao, Z; Woods, KW; Penning, TD; Souers, AJ Pyridine CDK9 kinase inhibitors US Patent  US9650358 Publication Date 5/16/2017 
Target
Name:
Cyclin-dependent kinase 9
Synonyms:
C-2K | CDC2L4 | CDK9 | CDK9_HUMAN | Cell division cycle 2-like protein kinase 4 | Cell division protein kinase 9 | Cyclin-Dependent Kinase 9 (CDK9) | Cyclin-dependent kinase 9 (CDK9) | Serine/threonine-protein kinase PITALRE | TAK | Tat-associated kinase complex catalytic subunit
Type:
Enzyme Subunit
Mol. Mass.:
42789.13
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
372
Sequence:
MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF
  
Inhibitor
Name:
BDBM307817
Synonyms:
(3R)-N-{5-chloro-4-[1-(4-fluorobenzyl)-1H-benzotriazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide | US9650358, Example 113
Type:
Small organic molecule
Emp. Form.:
C24H22ClFN6O
Mol. Mass.:
464.922
SMILES:
Fc1ccc(Cn2nnc3ccc(cc23)-c2cc(NC(=O)[C@@H]3CCCNC3)ncc2Cl)cc1
Structure:
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