Reaction Details Report a problem with these data
Target
Receptor-interacting serine/threonine-protein kinase 1
Ligand
BDBM571107
Substrate
n/a
Meas. Tech.
RIPK1 HTRF Binding Assay
IC50
2.00±n/a nM
Citation
 Mertzman, ME; Dzierba, CD; Guernon, JM; Hart, AC; Luo, G; Macor, JE; Pitts, WJ; Shi, J; Spergel, SH Aminoimidazopyridazines as kinase inhibitors US Patent  US11440913 Publication Date 9/13/2022 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 1
Synonyms:
Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
75926.99
Organism:
Homo sapiens (Human)
Description:
Q13546
Residue:
671
Sequence:
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
  
Inhibitor
Name:
BDBM571107
Synonyms:
N-({2-[cyclopropyl(deutero)methoxy]- 3,5-difluorophenyl}methyl)-5-{2- acetamidoimidazo[1,2-b]pyridazin- 6-yl}-2-(deutero)methoxy-6- methylpyridine-3-carboxamide | US11440913, Example 174 | US11440913, Example 177 | US11440913, Example 287 | US11440913, Example 300
Type:
Small organic molecule
Emp. Form.:
C27H26F2N6O4
Mol. Mass.:
536.5299
SMILES:
COc1nc(C)c(cc1C(=O)NCc1cc(F)cc(F)c1OCC1CC1)-c1ccc2nc(NC(C)=O)cn2n1
Structure:
Search PDB for entries with ligand similarity: